INTRODUCTION: Expression of the CUX1 gene – also known as CDP, CUX, p75, CASP, CDP1, COY1, Clox, p100, p110, p200, CUTL1, GOLIM6, CDP/Cut, Cux/CDP or Nbla10317 – has been observed elevated in pancreatic, breast and other cancers. Duplications and other anomalies in the region of the VIPR2 gene – also called VPAC2, VPAC2R, VIP-R-2, VPCAP2R, PACAP R3, DUP7q36.3, PACAP-R-3 or C16DUPq36.3 – are associated with schizophrenia, prenatal malformations and some intestinal malignancies.
INTENDED USE: The CUX1/VIPR2/CCP7 FISH Probe Kit is designed to detect the human CUX1 gene located on chromosome band 7q22.1, and the VIPR2 gene on chromosome band 7q36.3, along with the number of chromosome 7 copies per cell.
PROBE DESCRIPTION: The VIPR2 Probe of the CUX1/VIPR2/CCP7 FISH Probe Kit labeled with the fluorochrome CytoOrange covers a chromosomal region which includes the entire CUX1 gene. The CUX1 Probe of the CUX1/VIPR2/CCP7 FISH Probe Kit labeled with CytoGreen covers a chromosomal region which includes the entire VIPR2 gene. The CCP7 Probe of the CUX1/VIPR2/CCP7 FISH Probe Kit labeled with the fluorochrome CytoAqua is derived from chromosome 7-specific alpha satellite DNA, is designed to serve as a control to determine the number of chromosome 7 copies per cell.
The probes are designed measure the copy number of the human CUX1 and VIPR2 genes located on chromosome bands 7q22.1 and 7q36.3, respectively.