پروب فیش PML-RARA Fusion/Translocation FISH Probe

INTRODUCTION:PML gene encodes in humans a protein calledPromyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19). PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatinof the cell nucleus. The RARA gene encodes in humans a nuclear receptor protein called Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1). Rearrangements between the two genes have been observed in acute promyelocytic leukemia and other malignancies.
INTENDED USE: The PML-RARA Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human PML and RARA genes, located on chromosome bands 15q24.1 and 17q21.2, respectively.

PROBE DESCRIPTION: The RARA Probe of the PML-RARA Fusion/Translocation FISH Probe labeled with the fluorochrome CytoGreen overs a chromosomal region including the entire RARA gene and some sequences upstream (5′ start) and downstream (3′ end) of the gene. The PML Probe of the PML-RARA
Fusion/Translocation FISH Probe labeled with the fluorochrome CytoOrange covers a chromosomal region which includes the entire PML gene and some
sequences around the gene.