Name: Antibody Retinoblastoma clone same as Rb1) 1F8
Description and applications: Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. 90% of neoplasias express moderately or intensely pRb (carcinomas of the breast, colon, stomach, endometrium, head and neck, lung, neuroendocrine, gliomas, lymphomas, melanoma, ovarian, pancreatic, kidney, urothelial, cutaneous and thyroid). The alteration of the Rb gene with the absence of nuclear expression of pRb has been demonstrated in some human tumors, including retinoblastoma, breast carcinoma, prostate cancer, lung cancer and some sarcomas.
Composition: Anti-human Retinoblastoma mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
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