Category: immunohistochemistry
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی CD38 کلون 38C03 برند Vitro
Name: CD38 Monoclonal Antibody clone 38C03
DESCRIPTION AND APPLICATIONS: CD38 is a single chain type II integral transmembrane protein, which is highly expressed on thymocytes. It is also present on activated T cells and terminally differentiated B cells (plasma cells). Other reactive cells include NK cells, monocytes, macrophages, and dendritic cells. CD38 may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is, however, not found on most mature resting peripheral lymphocytes. CD38 functions as a multicatalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells.
COMPOSITION: Anti-human CD38 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
INTENDED USE: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting
IMMUNOGEN: Recombinant protein encoding the extracellular domain of human CD38.
SPECIES REACTIVITY: In vitro diagnostics in humans. Not tested in other species
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آنتی بادیهای ایمونوهیستوشیمی
آنتی بادی CD45 کلون 2B11 & PD7/26 برند Vitro
Name: CD38 Monoclonal Antibody clone 2B11 & PD7/26
DESCRIPTION AND APPLICATIONS: Anti-CD45 (anti leukocyte common antigen) is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; therefore a positive result is highly indicative of hematolymphoid origin. Certain types of hematolymphoid neoplasms may lack CD45(Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
COMPOSITION: Anti-human CD45, also known as leukocyte common antigen, is a mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
INTENDED USE: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting
SPECIES REACTIVITY: In vitro diagnostics in humans. Not tested in other species
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آنتی بادیهای ایمونوهیستوشیمی
آنتی بادی CD42b کلون EPR19204 برند Vitro
Name: CD42b Monoclonal Antibody clone EPR19204
DESCRIPTION AND APPLICATIONS: The CD42b glycoprotein, also known as GPIb, is a co-factor of ristocetin-induced aggregation and is involved in the binding of platelets to blood vessel walls. The CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. The absence of CD42b antigen on platelets may indicate Bernard Soulier disease. The antibody is of value in theimmunophenotyping of megakaryoblastic leukaemias that express one or more markers associated with platelets (CD41, CD61 and CD42b). In chronic myeloproliferative processes, like chronic idiopathic myelofibrosis in prefibrotic stage besides appearing in greater numbers the megakaryocytes are markedly abnormal while megakaryocytes in unclassifiable myelodysplastic / myeloproliferative diseases there is an increased of normal or small megakaryocytes (micromegakaryocytes).
COMPOSITION: Anti-human CD42b rabbit monoclonal antibody purified from hybridoma and, diluted in a pH7.6 buffer containing stabilizing protein and sodium azide as bacteriostatic and bactericidal agent.
INTENDED USE: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting
IMMUNOGEN: Recombinant CD42b.
SPECIES REACTIVITY: In vitro diagnostics in humans. Not tested in other species
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آنتی بادیهای ایمونوهیستوشیمی
آنتی بادی Cdk4 کلون CDK4/7987R برند Vitro
Name: Cdk4 Monoclonal Antibody clone CDK4/7987R
DESCRIPTION AND APPLICATIONS: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2 Cdk8, PCTAIRE-1-PCTAIRE-3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK).
COMPOSITION: Anti-human CDK4 rabbit monoclonal antibody diluted in a pH 7.6 buffer containing stabilizing protein and sodium azide as bacteriostatic and bactericidal agent.
INTENDED USE: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting
IMMUNOGEN: Recombinant fragment corresponding to N-terminal of human CDK4 protein
SPECIES REACTIVITY: In vitro diagnostics in humans. Not tested in other species