آنتی بادی PIT-1/POU1F1 (polyclonal)

Name: Rabbit Anti-Human PIT-1/POU1F1 Polyclonal Antibody

Description and aplications: The PIT-1 molecule (pituitary-specific transcription factor 1, also known as POU1F1 or GHF-1) belongs to the POU group of transcription factors involved in development together with OCT1 and Unc-06. It is
encoded by a gene located on chromosomal region 3p11.2. PIT-1 is involved in the differentiation and development of anterior pituitary cells, secreting hormones with lactotropic, somatotropic and
thyrotropic activity (beta subunit). It is also involved in the activation of genes controlling growth hormones and prolactin. Heterogeneous (homo- and heterozygous) mutations of PIT-1 lead to combined pituitary deficiency type 1 which is clinically characterized by irreversible mental and growth retardation and presents deficient plasma levels of growth hormone, combined mainly with low levels of prolactin or TSH. In contrast, ACTH, LH or FSH levels remain within normal values in this disease. Acquired combined pituitary deficiency has also been described, in which patients do not have mutations of the PIT-1 gene but nevertheless have low plasma levels of free TSH and free T4 along with undetectable levels of growth hormone and prolactin. In these cases, the disease is associated with the presence of autoantibodies to PIT-1, microsomes, thyroglobulin, thyroid peroxidase, GAD, and parietal cells of the stomach. PIT-1 staining of pituitary adenomas is similar to that of the normal gland. Although PIT-1 is not routinely used to characterize these neoplasms, in the case of non-functioning adenomas that have tested negative for the first panel of antibodies of
pituitary hormones, the combined use of PIT-1, T-PIT and SF-1 antibodies can differentiate PIT-1-positive adenomas from true null adenomas.

Composition: Anti-human PIT-1/POU1F1 rabbit polyclonal antibody obtained from ascitic fluid and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: Recombinant protein corresponding to human PIT-1/POU1F1.