| Clone | QR003 |
|---|---|
| REF | C-H001 |
| Dilution | 1:100 – 1:100 |
| Immunogen | Synthetic peptide of human Her2 |
| Isotype | IgG |
| Species of origin | Rabbit |
Her2/Neu is a member of human epidermal growth factor family and encodes for a receptor tyrosine kinase involved in signal paths of growth factors.
Her2/Neu activation occurs in various tumors, mostly through gene amplification which results in high level overexpression. Her2/Neu amplification and overexpression is particularly common in breast cancer but can – at lower frequency – also occur in many other tumor entities. Numerous studies have demonstrated the prognostic relevance of Her2/Neu, which is overexpressed in 10% to 40% of human breast tumors.
