Name: Alpha-1-antichymotrypsin Antibody
Description and applications: This antibody reacts with the human alpha-1- antichymotrypsin, a surfactant protein in acute phase of the inflamation, plus a serpin that inactivates preferably the chymotrypsin, the cathepsin G and the chymase. As an inhibitor protein of serine protease, it is closely related to the neuritic plaques in the Alzheimer’s disease and in human and monkey brains with normal aging signs. The regulation of serine proteases and their inhibitors have an important function in the neuromuscular pathology differential diagnosis. The alpha-1-antichymotrypsin binds primarily to the prostate specific antigen (PSA), a serine protease similar to the chymotrypsin, to form a complex. Furthermore, this antibody can be used to identify hematopoietic cells of the monocyte-macrophage series and neoplasias derived from them.
Composition: anti-human Alpha-1-Antichymotrypsin rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
Ig isotype: Rabbit IgG
IHC positive control: Macrophages in the tonsils.