| Clone | QR021 |
|---|---|
| REF | C-C006 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human CD10 |
| Isotype | IgG |
| Species of origin | Rabbit |
CD10 (CALLA, neprilysin) is a zinc-dependent metalloprotease enzyme that degrades various bioactive peptides and plays a functional role by modulating cellular responses to peptide substrates. CD10 is a membranous marker with extensive expression in normal tissues. It is reported to be critical for use in diagnosis and subclassification of leukemias (B lymphoblastic leukemia, mixed phenotype acute leukemia, etc.) and lymphomas (follicular lymphoma, Burkitt lymphoma, diffuse large B cell lymphoma, angioimmunoblastic T cell lymphoma, etc.).
Anti-CD10 is found in 60-70% of hepatocellular carcinoma (distinct canalicular pattern), in about 90% of renal cell carcinoma (clear cell and papillary types, but less chromophobic type), in 50-70% of urothelial carcinoma (particularly high grade), and in 60-73% of prostate carcinoma (particularly high grade and aggressive).
