آنتی بادی Cytokeratin 20 (KS20.8)

.Name: CytoKeratin 20 Antibody Clone Ks20.8

Description and aplications: Keratins (also known as cytokeratins) are intermediate filament/forming proteins that represents the main cytoskeleton of epithelial cells. They classically are classified based on Moll cataloging which grouped the basic-to-neutral type II keratins as K1–K8 and the acidic type I keratins as K9– K19. An updated classification including 24 types of keratins was then proposed in order to enable other mammalian species keratins to be added.  Keratin 20 / cytokeratin20 (CK20) is a Type-I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. CK20 is expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system. CK20 is also present in mucinous ovarian tumors, transitional-cell and Merkel cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, nonmucinous tumors of the ovary, and small cell carcinomas lack in CK20.

Composition: anti human keratin 20 mouse monoclonal antibody obtained from supernatant culture and prediluted in a Tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.

Immunogen: semi-purified human cytokeratin preparation.