| Clone | QR096 |
|---|---|
| REF | C-C020 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human Chromogranin A |
| Isotype | IgG |
| Species of origin | Rabbit |
Chromogranin A is a member of the granin family of neuroendocrine secretory proteins and is located in secretory vesicles of neurons and endocrine cells. It regulates function of secretory granula, is involved in hormone processing and secretion, and is disassembled to biologically active peptides.
Chromogranin A is the most important and most common granin in neuroendocrine tumors. Antibody Chromogranin A is the single most specific marker for such tumors including anterior pituitary, gastrointestinal tract, pancreas, thyroid and lung as well as neuronal tumors and merkel cell carcinomas. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
