| Clone | QR002 |
|---|---|
| REF | C-P002 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human PD-1 |
| Isotype | IgG |
| Species of origin | Rabbit |
Programmed Death 1 (PD-1; CD279) is a transmembrane protein functioning as surface receptor for its ligands PD L1 and PD-L2. PD-1 is expressed mainly on activated T cells, B-cells and myeloid cells.
PD-1 is an immune checkpoint and plays a crucial role in down regulation of the immune system through inhibition of T-cell activation, which in turn reduces autoimmunity. Some tumor cells use this mechanism to prevent apoptosis by inhibiting T-cells directed to them. PD-1 is a useful marker for angioimmunoblastic lymphoma. Furthermore, increased expression of PD-1 has been found to be associated with poor prognosis in hepatocellular carcinoma and renal cell carcinoma. Treatments targeting PD-1 have shown encouraging results in breast cancer, non-small cell lung cancer (NSCLC) and melanoma.
