آنتی ­بادی Amyloid P (EP1018Y)

Name: Amyloid P Antibody clone EP1018Y

Description and applications: Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits. It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes. SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines. Recognition of these type of amyloid has prognostic and therapeutic implications. The increase in SAP secretion has been documented in different pathologies including neoplasms, rheumatoid arthritis
and CNS diseases. The synthesis of SAP is increased in systemic amyloidosis and is a common component in amyloid deposits. SAP has also been identified in arteriosclerotic lesions.

Composition: Anti-human Amyloid P rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.