Name:Mouse anti-human anti-CD44 Std./HCAM Monoclonal Antibody Clone 156-3C11.
Description and aopplications: CD44 is a transmembrane type I glycoprotein involved in adhesion between cells and different components of the extracellular matrix, expr many human tissues. CD44 is also known as homing cell adhesion molecule (H-CAM), Phagocytic glycoprotein-1 (PgP-1), ECM-III, HUTCH-1, or Hermes-1. This antibody recognize CD44 standard isoform (CD44std), which comprises exons 1-5 and 16-20, present in most cells as a glycoprotein of approximately 90 kDa that acts as the main ligand for hyaluronic acid. For its behavior as a receptor for hyaluronic acid, CD44s molecule which is expressed on leukocytes including many T and B lymphocytes, medullary thymocytes, monocytes and granulocytes, plays an important role in intercellular adhesion of cells to the basement membrane and in maintaining its polarity. In tumors, the loss of CD44s expression is generally considered a factor of poor prognostic and in most cases is associated with the presence of distant metastases. Besides determining CD44s may be useful in the diagnosis of malignant urothelial lesions in their early stages, which would be characterized by a membrane staining restricted to the basal layers of the transformed epithelium compared with diffuse staining normally present in the normal urothelium.
Composition: anti-human CD44std mouse monoclonal antibody purified from ascites fluid by Protein A chromatography. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
.Immunogen: Stimulated human leukocytes