آنتی بادی PAX-2 (EP235)

name: PAX-2 Antibody clone EP235

Description and aplications: PAX2 is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and müllerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. Defects in PAX2 gene are related with the renal coloboma syndrome (RCS) (also known as papillorenal syndrome) which is a condition that primarily affects kidney (renal) and eye development. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, uretericepithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms’ tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. For these reasons, PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry. It has been also suggested as a useful tool in diagnosis and classification of hyperplastic endometrial epithelial proliferations

Composition: anti-human PAX2 rabbit monoclonal antibody purified from ascites fluid by chromatography. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide