آنتی بادی Carbonic Anhydrase 9 (EP161)

(Name: Rabbit anti-human Carbonic Anhydrase 9 Monoclonal Antibody (Clone EP161.

Description and applications: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and subcellular localization. Carbonic Anhydrase 9, a member of the carbonic anhydrase family, is thought to play a role in the regulation of cell proliferation in response to hypoxic conditions and may be involved in oncogenesis and tumor progression.Carbonic Anhydrase 9 (CA9) has a distinctive expression pattern in normal and cancer tissues. The most abundant expression of CA9 was found in normal mucosa of the stomach and gallbladder. Other normal tissues have lower or no expression. Relatively high levels of CA9 are expressed in carcinomas of the cervix, kidney, lung, breast and many other tumors. Most studies have shown that decreased CA9 levels are independently associated with poor survival. Low levels of CA9 maybe benefit more from adjuvant treatment than patients with high levels.

COMPOSITION: Anti-human Carbonic Anhydrase 9 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

IMMUNOGEN: A synthetic peptide corresponding to residues in the extracellular domain in human Carbonic Anhydrase 9 was used as an immunogen.