Name: CD5 Antibody Clone EP77
Description and applications:CD5 (Lymphocyte antigen T1/Leu-1) is a transmembrane glycoprotein which has been implicated as a receptor in the regulation of T-cell proliferation. CD5 antibody labels a variety of T lymphocytes, mantle zone lymphocytes and a small subset of B lymphocytes. In tumors, CD5 is expressed on T-cell malignancies, B cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), and mantle-cell lymphoma. As CD5 is expressed in activated T lymphocytes and in several T-cell leukemias, it must be included in the panel of immunophenotypic study of T cell lymphomas as it is positive in mycosis fungoides and is deleted in most Tcell anaplastic lymphomas (ALK), lymphomatoid papulosis, and blastoid NK / T lymphomas. In addition, anti-CD5 is helpful in diagnosis of thymic carcinoma (CD5 positive).
Composition: Anti-human CD5 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
IMMUNOGEN: A synthetic peptide corresponding to
residues in human CD5 protein.