آنتی‌ بادی Heat Shock Protein 70 (HSP70) (W27)

Name: Heat Shock Protein 70 (HSP70) Monoclonal Antibody clone W27

Description and applications: Heat shock proteins (HSP’s) or stress response proteins (SRP’s) are synthesized in variety of environmental and pathophysiological stressful conditions. Many HSP’s are involved in processes such as protein denaturation-renaturation, folding-unfolding, transporttranslocation, activation-inactivation, and secretion.HSP70 is found to be associated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and other unknown proteins. Also, HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs, and other damaging conditions. This antibody recognizes both the constitutive (HSP73), and inducible (HSP72) forms of HSP70. Most normal cells show moderate cytoplasmic and nuclear immunostaining. Pancreatic islets, cardiac muscle cells and most CNS cells are weakly stained or negative. HSP70 in tumors is significantly increased in patients with cholangiocarcinoma. HSP70 is positive in the majority of the hepatocellular carcinoma. In oral squamous cell carcinomas HSP70 expression has been associated with increased survival compared with HSP70 negative tumors, suggesting that low HSP70 expression in epidermoid carcinomas require more aggressive treatment.

Composition: anti-human HSP70 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Immunogen: HSP70 protein from HeLa cells

Species reactivity: In vitro diagnostics in humans. Not tested in other species