Name: P16 INK4A Antibody-Clone MX007
Description and applications: As one of the cyclindependent kinase inhibitors that inhibit cylcindependent kinases 4 and 6, p16 INK4A is encoded by tumor suppressor gene CDKN2A. The tumor suppressor p16 INK4A plays an important role in cell cycle regulation. Increased expression of the p16 gene, which is seen as organisms ages, reduces the proliferation of stem cells. This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence. Mutations in the p16 gene associated with loss or over expression of the protein are associated with increased risk of a wide range of cancers and cancer precursor lesions. The immunohistochemical identification of p16 is particularly relevant in uterine cervical lesions. Development of dysplasia is closely related to human papilloma virus (HPV) infection. Although the frequency of p16INK4a abnormalities is higher in tumor-derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.
Composition: anti-human p16INK4A mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.