Specification:
CD1a is a non-polymorphic major histocompatibility complex class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with β-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating dendritic cells, and rare antigen-presenting cells of the lymph node. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a was reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Presentation:
Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
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