آنتی بادی PAX-8 (MD-50 also known as MRQ-50)

Name: Pax-8 Antibody clone MD-50 also known as MRQ-50

Description and applications:PAX8 antibody recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX8 is expressed in the normal thyroid follicular cells and associated carcinomas. As a marker of mesonephric and müllerian organs, ovarian and renal normal and neoplasms are frequently positive. For that, non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts and normal ovarian surface epithelial cells are positive. PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors as it is expressed by all the segments of the nephron and the great majority of renal tumours including sarcomatoid carcinomas. Thymic and parathyroid carcinomas and isolated cases of urothelial carcinomas, sex-cord stromal tumours of the ovary or squamous carcinomas of the lung have showed weak and focal positivity.

Composition:Anti-human PAX-8 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide