.(Name: Thyroid Transcription Factor 1 (TTF-1)(clone SPT24
Description and aplications:This antibody recognizes a protein identified as thyroid transcription factor 1 (TTF-1), a member of the Nkx2 family homeodomain transcription factors. This antibody was designed against a short recombinant peptide and shows great sensitivity and provides a stronger and less cytoplasmic unspecific staining or cross-reaction with tissues other than thyroid and lung. The clone SPT24 identifies the presence of TTF-1 in thyroid follicular epithelium, as well as type II pneumocytes and Clara cells of the lung and their corresponding tumors. It can also be observed in certain brain reactive glial cells and some cases of colon adenocarcinomas. It shows no nuclear staining in a variety of normal tissues and no cytoplasmic reactivity was described in hepatocarcinomas.
Composition: anti- TTF1 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal. The quantity of the active antibody was not determined.
.Immunogen: recombinant protein molecule corresponding to a fragment of 123 AA of the N-terminal region of human TTF-1