پروب فیش DLEU1/ZBTB16 FISH Probe

INTRODUCTION:The DLEU1 gene was originally identified as a potential tumor suppressor gene.The ZBTB16 gene is a member of the Kruppel C2H2 type zinc finger protein family and encodes a transcription factor containing nine Kruppel-type zinc finger domains at the C-terminus. The ZBTB16 protein is located in the cell nucleus and is involved in the progression of the cell cycle, interacting with histone deacetylases. Rearrangements and abnormal expression of the DLEU1 gene region – also known as BCMS, DLB1, LEU1, LEU2, XTP6, BCMS1, DLEU2, LINC00021 or NCRNA00021 – have been observed in B-cell chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and other malignancies. Fusions and aberrant expression of the ZBTB16 gene – also known as PLZF or ZNF145 – have been reported in acute promyelocytic leukemia and other neoplasias.
INTENDED USE: The DLEU1/ZBTB16 FISH Probe Kit is designed to detect the human DLEU1 gene, located on chromosome band 13q14.2, and the ZBTB16 gene on chromosome band 11q23.2.

PROBE DESCRIPTION:The DLEU1 Probe of the DLEU1/ZBTB16 FISH Probe kit labeled with the fluorochrome CytoOrange covers a chromosomal region which includes the majority of the DLEU1 gene and genomic sequences adjacent to the 5′ end of the gene. The ZBTB16 Probe of the DLEU1/ZBTB16 FISH Probe Kit labeled with CytoGreen e covers a chromosomal region which includes the entire ZBTB16 gene. Both probes are designed to measure the copy number of the human DLEU1 and ZBTB16 genes located on chromosome bands 13q14.2 and 11q23.2, respectively.