آنتی‌ بادی PCNA (PC10)

Name: PCNA (Proliferating Cell Nuclear Antigen) Monoclonal Antibody clone PC10

Description and aplications: Expression of proliferating cell nuclear antigen (PCNA) or cyclin or polymerase delta auxiliary protein is elevated in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. Its level correlates directly with rates of cellular proliferation and DNA synthesis. PCNA/cyclin may act as an auxiliary protein of DNA polymerase-delta to play a fundamental role in the initiation of cell proliferation The level of PCNA expression is directly related to the rate of cell proliferation and DNA synthesis. PCNA / cyclin could act as an auxiliary protein of DNA polymerase delta, which plays an essential role in the initiation of cell proliferation.This antibody is useful tool for studying the proliferating cells in normal tissues and its potential aberrant expression in neoplasms

Composition: anti-human PCNA mouse monoclonal antibody purified from ascites fluid by Protein A chromatography. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Immunogen: Recombinant rat PCNA protein