آنتی‌ بادی Progesterone Receptor (16)

Name: Mouse Anti-Progesterone Receptor (PR) Monoclonal Antibody clone 16

Description and applications: This mouse monoclonal antibody clone 16 it has been demonstrated to react with both A and B forms of human progesterone receptor by Western blotting procedure. In normal conditions, the nuclear expression of PR occurs in the acinary cells of the breast, endometrium (proliferative phase glands and stroma are strongly positive while absence or variable expression is noted in the secretory phase glands and stroma) myometrium and superficial cervical stroma. PR along with estrogen receptors, Cerb-B2, Ki-67 and p53 are considered to have prognostic value in breast cancer. As the neoplastic growth is hormone dependent, the increased expression of PR is associated with a better response to Tamoxifen-treatment in breast cancers. PR determination is also useful in gynecologic pathology where is positive in endometrial adenocarcinoma, stromal sarcomas or leiomyomas. Meningiomas also show positivity for the PR.

Composition: anti-PR mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.

Immunogen: Recombinant protein encoding N-terminal region of human progesterone receptor.