آنتی‌ بادی p63 (4A4)

Name: Mouse anti-human p63 Monoclonal Antibody clone 4A4

Description and aplications: p63, a homolog of the tumor suppressor p53, has been identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with reported sensitivities of 80-100%. Specificity for lung SqCC, vs. lung adenocarcinoma, has been reported to be approximately 70-90%, as positive staining with p63 has been typically observed in 10-30% of lung adenocarcinomas cases. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts. Reports have described the utility of p63 in a panel of IHC markers for the assessment of breast lesions, due to the differential expression of the luminal vs. basal and myoepithelial markers.

Composition: anti-human p63 mouse monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide