آنتی‌بادی Pan-Cadherin (CH-19)

Name:Pan-cadherin Antibody clone CH-19

Description and applications: Cadherins are a broad family of cell-cell adhesion molecules with varying degrees of tissue expression. E-cadherin is found in all normal epithelia, whereas Pcadherin is expressed in trophoblastic cells and shows limited expression in epithelia, being predominantly expressed in bronchial and mammary basal epithelia. Cadherins are calcium-dependent adhesion molecules; intracellularly, E-cadherin binds to members of the catenin family (β, γ or α-catenins), which in turn are connected to the cytoskeleton’s actin filaments. Cadherins play an important role in cell growth and development, maintaining tissue integrity and architecture. Loss of cadherin expression plays an important role in neoplasms, facilitating local invasion and metastases generation. Immunohistochemical studies on carcinomas show decreased cadherin expression compared to normal tissues, especially in highly invasive tumours such as gastric adenocarcinomas.

Composition: Anti-human Pan-Cadherin mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide