آنتی‌ بادی Pancreatic lipase (EPR6275)

Name: Pancreatic lipase Antibody clone EPR6275

Description and applications: Pancreatic lipase is a 56kDa molecular mass enzyme actively secreted in the duodenum by the pancreas in the presence of bile salts and colipase. It belongs to the family of triglyceride lipases, of which there are at least three tissue-specific isoenzymes (pancreatic, hepatic and gastric and lingual) that break down dietary fats by converting triglycerides into monoglycerides and free fatty acids. Pancreatic lipase together with bile salts favors the absorption into the lymphatic system of the monomers resulting from digestion. Human pancreatic lipase is encoded by the PNLIP gene of 13 exons and more than 20 kb, located on the chromosomal region 10q25.3. In normal tissues this antibody identifies pancreatic acinar cells and in neoplasms it recognizes acinary cell carcinoma of the pancreas, which expresses this marker in more than 50% of cases. For this reason and integrated in a panel of suitable antibodies, pancreatic lipase allows the differentiation of acinar adenocarcinoma of pancreas from other malignancies with similar morphology (especially neuroendocrine carcinoma with acinary architecture) and establish the pancreatic origin of distant metastases, that on numerous occasions may be the first manifestation of the tumor.

Composition: Anti-human Pancreatic lipase mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide