آنتی ­بادی CDX-2 (EP25)

Name: CDX2 Antibody Clone EP25

Description and applications: The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract. Most of the mucinous adenocarcinomas of the ovary, ampullary, gastric or esophageal adenocarcinomas show immunoreactivity for CDX2 even though,heterogeneous and less intense than in colorectal carcinomas. In endometrial and pancreatic adenocarcinomas CDX2 expression it is exceptional while breast adenocarcinomas, including the mucinous ones, stain negative for CDX2. Approximately 10% of lung adenocarcinomas may be positive for CDX2.

Composition: anti-human Thyroglobulin rabbit monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: A synthetic peptide corresponding to residues near the C-term of human CDX-2 protein.

Name: CDX2 Antibody (Clone EP25)

Description and applications: The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract. Most of the mucinous adenocarcinomas of the ovary, ampullary, gastric or esophageal adenocarcinomas show immunoreactivity for CDX2 even though,heterogeneous and less intense than in colorectal carcinomas. In endometrial and pancreatic adenocarcinomas CDX2 expression it is exceptional while breast adenocarcinomas, including the mucinous ones, stain negative for CDX2. Approximately 10% of lung adenocarcinomas may be positive for CDX2.

Composition: anti-human Thyroglobulin rabbit monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: A synthetic peptide corresponding to residues near the C-term of human CDX-2 protein.