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Name: Epstein-Barr Virus / LMP1   (Clone CS1-4)

Description and applications:The antibody strongly reacts with EBV-positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. It also reacts with 25 to 50 per cent of EBV associated undifferentiated nasopharyngeal carcinomas and with Reed Sternberg cells in approximately 90% of EBVassociated Hodgkin’s disease cases. The cocktail recognizes distinct epitopes on the hydrophilic carboxyl region of LMP which is exposed to the cytosol.

Composition:Anti-human Epstein-Barr Virus / LMP1 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: EBV-encoded recombinant latent membrane protein.

Name: Fascin  (Clone FCN01)

Description and applications:Anti-Fascin is a very sensitive marker for ReedSternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin’s disease. It is uniformly negative in lymphoid cells, plasma cells and myeloid cells. Anti-Fascin is positive in dendritic cells. This marker may be helpful in distinguishing between Hodgkin’s disease and nonHodgkin’s lymphoma in difficult cases. Also, the lack of expression of Fascin in the neoplastic follicles in follicular lymphoma can be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Anti-Fascin has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung, as well as ovarian cancer.

Composition: Anti-human Fascin mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Name: Glutamine Synthetase  (Clone GS-6)

Description and applications:Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver. In normal liver, GS expression is seen in pericentral hepatocytes, but not in mid-zonal or periportal hepatocytes. Glutamine, the end product of GS activity, is the major energy source of tumor cells. Based on findings from experimental hepatocarcinogenesis, GS positive tumor cells are believed to be derived from GS positive hepatocytes. Thus, anti-GS has been suggested as a marker for hepatocellular carcinoma (HCC). GS immunoreactivity has been seen in a majority of HCC (37 of 53 cases, 70%), including 7 of 10 cases of early HCC (70%) and 12 of 22 (59%) for low grade HCC. In nonmalignant nodules, GS overexpression was only seen in 3 high grade dysplastic nodules (HGDN,13.6%). In these cases, GS overexpression was restricted to 11.5%-50% of hepatocytes, whereas in HCC the majority of cases (28 of 53, 53%), including early HCC (60%), showed diffuse immunostaining (>50% tumor cells). Overall, the sensitivity, specificity, and positive and negative predictive values of anti-GS for HCC detection were 69.8%, 94.2%, 92.5%, and 75.4%, respectively. A panel composed of antibodies against HSP70, GPC3, and GS has been proposed to be very useful in distinguishing between dysplastic and early malignant hepatocellular nodules arising in cirrhosis. The “all positive” phenotype is restricted to approximately half of early HCC to well-differentiated HCC but has never been reported in dysplastic lesions, whereas the reverse phenotype, “all negative”, has been shown to be a feature of the majority of HGDN and of all low grade dysplastic nodules.

Composition: Anti-human Glutamine Synthetase mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

name: PAX-2 Antibody clone EP235

Description and aplications: PAX2 is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and müllerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. Defects in PAX2 gene are related with the renal coloboma syndrome (RCS) (also known as papillorenal syndrome) which is a condition that primarily affects kidney (renal) and eye development. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, uretericepithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms’ tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. For these reasons, PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry. It has been also suggested as a useful tool in diagnosis and classification of hyperplastic endometrial epithelial proliferations

Composition: anti-human PAX2 rabbit monoclonal antibody purified from ascites fluid by chromatography. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

 Name: PAX-5 Antibody clone MX017

Description and applications: The PAX-5 gene is essential for B-cell differentiation. There are at least four isoforms, of which PAX-5a has been most studied. PAX-5 encodes the 50 kDa B-cell specific activator protein, BSAP. PAX-5 is expressed by pro-, pre-, and mature B-cells, but is downregulated during terminal differentiation of plasma cells. PAX-5 influences the expression of other B-cell specific genes, including CD19 and CD20 and CD79a, preceding the expression of CD20. PAX-5 is silenced at the plasma cell stage under the influence of Blymphocyte-induced maturation protein-1 (PRDM1). Pax-5 is consistently expressed in mature B cell lymphomas. It is useful to distinguish between classical Hodgkin lymphoma (+) and ALCL (-). In Hodgkin lymphoma, the neoplastic cells show a weaker staining compared with the accompanying B cells. Occasionally it expressed in acute myeloid leukemias especially those with t (8; 21). CD20 negative B-cell lymphomas of patients treated with anti-CD20 monoclonal antibodies, maintain PAX5 staining the antibody representing a good tool to confirm their cell of origin. Pax-5 expression was detected in hyperplastic mesonephric remains, epididymitis, neurons of the adult nervous tissue, small cell carcinomas, Merkel cell tumor and other neuroendocrine tumors.

Composition: anti-human PAX5 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Name : Antibody Ca19-9 clone 121SLE

Description and applications: CA19-9 antigen is highly expressed in gastrointestinal (gastric, pancreatic, and colonic) adenocarcinomas and salivary gland mucoepidermoid carcinomas. Anti- CA19-9 antibody is usually not reactive with breast, kidney, and prostate carcinomas. Anti-human CA19-9 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Composition:Anti-human CA19-9 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Name: Pax-8 Antibody clone MD-50 also known as MRQ-50

Description and applications:PAX8 antibody recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX8 is expressed in the normal thyroid follicular cells and associated carcinomas. As a marker of mesonephric and müllerian organs, ovarian and renal normal and neoplasms are frequently positive. For that, non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts and normal ovarian surface epithelial cells are positive. PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors as it is expressed by all the segments of the nephron and the great majority of renal tumours including sarcomatoid carcinomas. Thymic and parathyroid carcinomas and isolated cases of urothelial carcinomas, sex-cord stromal tumours of the ovary or squamous carcinomas of the lung have showed weak and focal positivity.

Composition:Anti-human PAX-8 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Name:Cadherin 17 Antibody clone SP183

Description and applications: Cadherins represents a big family of Ca2+ dependent transmembrane cell adhesion glycoproteins that interact homophilically with each other and thus participate in the heterologous cell selection. They play a key role in the embryonic development and in the maintenance of the normal structure in adult tissues. Molecular defects in the structure of cadherins represent important pathogenic aspects of many diseases, including cancer. The cadherin 17 gene (CDH17) is located on the chromosome region 8q22.1 that encodes a protein of 832 amino acids and approximately 92kDa of molecular weight. Cadherin 17, also known as human peptide transporter 1 (HPT-1) or liver-intestine cadherin (LICadherin), is located in the lateral contact areas of the intestinal epithelial cells, being undetectable in the stomach, kidney, lung or liver, among other organs. It
features many structural similarities with the kidney specific cadherin, both belonging to the 7D-cadherin family. In tumors, the great specificity of cadherin 17 to identify the primary or metastatic colorectal adenocarcinomas has been demonstrated. Less frequently, cadNherin 17 has been described in gastroesophageal junction adenocarcinomas or adenocarcinomas with gastric origin. In the few available studies, cadherin 17 has shown staining in all well-differentiated neuroendocrine tumors (carcinoid tumors) originated in the small intestine and in the appendix. Up to 80% of the primary pancreatic adenocarcinomas and only half of their metastases are usually positive. Up to 50% of cholangiocarcinomas show membrane staining against cadherin 17, showing greater sensitivity than other markers such as villin, CDX2 or SATB2, which can be used to refine the diagnosis. Cadherin 17 shows along with SATB2 greater sensitivity in the detection of medullar carcinomas of the large intestine that are usually negative for CDX2 and cytokeratins 7 and 20.

Composition: Anti-human Cadherin 17 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Name: CD68 Monoclonal Antibody clone KP-1

Description and aplications: Anti-CD68 marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, NK cells, granulocytes and their precursors; lymphomas are negative or show a few granules. This antibody may be useful for the identification of myelomonocytic and histiocytic tumors. Anti-CD68 may help to distinguish malignant fibrous histiocytoma from other pleomorphic sarcomas. However, since this detects a formalinresistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also stain.

Composition: Anti-human CD68 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Name: Anti-human CDK4 Mouse Monoclonal Antibody clone DCS-35

Description and aplications: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression.
Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1-PCTAIRE-3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK).

Composition: Anti-human CDK4 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Intended use: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting

Name: CD95 Monoclonal Antibody clone EP208

Description and aplications: The CD95 (Fas) protein is a cell surface receptor belonging to the tumor necrosis factor (TNF) family that transduces death signaling on engagement by multimeric Fas ligand (CD95L), of which there are eight in its membrane–bound form or in its soluble form resulting from cleavage by a putative metalloproteinase. CD95 is a widely expressed protein. CD95-mediated apoptosis is an essential mechanism for the maintenance of normal tissue homeostasis, and disruption of this death pathway has been associated with a wide range of human diseases, including autoimmune diseases, lymphoproliferative disorders and malignancies. The Fas death system also plays important roles in various apoptosis conditions such as those evoked by irradiation, chemotherapeutic
agents and viral infections. The expression of CD95 serves as a prognostic marker in predicting the outcome of disease progression and treatment in many types of tumors.

Composition: Anti-human CD95 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide